Project 1: The Mouse Brain Library Project 2: Internet Microscopy (iScope) Project 3: Neurocartographer and Segmentation of the MBL Project 4: The Neurogenetics Tool Box


















Principal Investigator/Program Director Williams,Robert W.

  Novelty of the neuroinformatics component.

What is the bioinformatics challenges of Internet microscopy that we will address in this project? There are a significant number of informatics, database, and connectivity bandwidth problems associated with effectively controlling a microscope over the network. We will come back to these shortly. One of the major challenge is in assembling an entire suite of applications and images that allows a neuroscientists to sweep through a large collection of slides from the lowest power to the highest power without actually having physical access to either the slides or a microscope. In our Phase I research we have clearly demonstrated our competence to individually deal with the low and high-power microscope independently, but the informatics challenge now is to bridge that large gap using two complementary approachesreal time imaging and analysis of pre-recorded high-magnification virtual tissue. By virtual tissue we mean 3D stacks of images that when played back on a computer give a neuroscientists the same feel for the tissue that they would have in turning the focus control at the microscope.

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  Limitations and Problems.