CURRICULUM VITAE

 

 

Name:      Lu Lu

Office Address:

Department of Anatomy and Neurobiology
University of Tennessee
Health Science Center
855 Monroe Avenue
Memphis TN 38163  

Phone:     901-448-7557 (O); 901-448-7018 (Lab)

Fax:         901-448-7193 (Dept); 901-448-1716 (Lab)

Email:     lulu@utmem.edu

 

EDUCATION

1998-1999: Postdoctoral Research Fellow, Department of Medicine, College of Physicians & Surgeons, Columbia University, New York

1984-1987: M.S. in Neuroscience, Shanghai Medical University, Shanghai

1977-1982: M.D. in Medicine, Nantong Medical College, Nantong

 

PROFESSIONAL EXPERIENCE

2006-present: Associate Professor, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee

2001-2005: Assistant Professor, Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee

2001-present: Professor, Department of Histology & Embryology, Nantong University

1999-2001: Visiting Research Fellow, Center for Neuroscience, University of Tennessee

1994-1998: Associate Professor, Director of Department of Histology & Embryology, Tenure review committee member of Nantong Medical College

1989-1994: Lecturer, Department of Histology & Embryology, Nantong Medical College

1987-1989: Teacher Assistant, Department of Histology & Embryology, Shanghai Medical University

1982-1984: Research Associate, Diving Physiology Research Institute, Shanghai

 

RESEARCH SUPPORT

2007-2009: Co-investigator, NIMH. Genetic analysis of Htr2c RNA editing in amygdala, R21MH077942-01A1 (PI: David Airey), TDC ~$250K over 2 years (07.01.07-06.30.09)

2004-2009: Principal Investigator: NIAAA. Genetic analysis of ethanol-mediated stress reduction, R01 converted to INIA U01AA14425. TDC ~$1.6M over 5 years (06.01.04–05.31.09).

2005-2010: Co-investigator, NIMH. Mapping Cerebellar Development in Time and Space, R01MH74460 (PI: Daniel Goldowitz), TDC ~$2.7M over 5 years (07.01.05–06.30.10)

2005-2010: Co-investigator, NIMH. Informatics Center for Mouse Neurogenetics, P20 DA-021131-06 (Robert Williams), TDC ~$5.5M over 5 years (09.01.05–08.31.10)

2004-2009: Co-investigator, NCI. Integrative genetics of cancer susceptibility, U01-CA105417-01  (PI: David Threadgill), TDC ~$0.84M over 5 years (04.01.04–03.31.09)

2002-2006: Coinvestigator, NIAAA. Complex trait analysis of alcohol-stress interaction U01AA13499 (PI: Robert Williams), TDC ~$1.68M over 5 years (02.01.02–12.31.06).

2002-2006: Coinvestigator, NIAAA. Genotyping Core, U24AA13513 (PI: Robert Williams), TDC ~$0.88M over 5 years (01.01.02–12.31.06).

1998-2000: Principal Investigator, Jiangsu Natural Science Foundation of China. ÒChanges of thrombopoietin (TPO) in platelet physiology and pathologyÓ

1995-1998: Principal Investigator, Nantong Medical College. Study on NGF gene expression in non-nervous tissues

1992-1995: Investigator, National Natural Science Foundation of China. NGF and its receptor genes expression in an animal model (rat) of Alzheimer's disease

1991-1993: Principal Investigator, Nantong Medical College. In vitro study of neurotrophic factor and dopaminergic neurons

1990-1993: Coinvestigator, National Natural Science Foundation of China. In vitro culture and transplantation of mesencephalic dopaminergic neurons of human and rat

1986-1989: Investigator, National Natural Science Foundation of China. Study of distribution and application of neuron-specific enolase in nervous and endocrine systems

 

AWARDS

1999   Award, May Day Prize of Jiangsu, China

1997   Remarkable Leader in Research and Technical Project Across the Century Named as 333 of Jiangsu, China

1997   Award for May Day Special Prize, Nantong City

1996   Excellent Teacher, Universities in Jiangsu, China

1994   Outstanding Researcher, Nantong Medical College

1994-1995   Prize for the Advancement of Science Research, Nantong Medical College

1991-1993   Prize for the Advancement of Science Research, Nantong Medical College

 

PROFESSIONAL SOCIETY MEMBERSHIPS

American Association for the Advancement of Science

Research Society Alcoholism

Society for Neuroscience

Behavior Genetics Association

International Mammalian Genome Society

International Complex Trait Consortium

International Behavioural and Neural Genetics Society

 

TEACHING

Class teaching:

1984-1989  Medical Histology, Shanghai Medical University

1984-1989  Medical Embryology, Shanghai Medical University

1989-1998  Medical Histology, Nantong Medical College

1989-1998  Medical Embryology, Nantong Medical College

1993-1998  Molecular Biology, Nantong Medical College

 

Supervisor for rotation PhD students in Department of Anatomy and Neurobiology, University of Tennessee:

2000~2001: Chunyan Li, Xudong Wu

2001~2002: Jianliang Xu, Xianghong Yang, Lai Wei

2002~2003: Jufang Shan

2003~2004: Jie Shen

2004~2005: Khyobeni Mozhui

2006~2007: Samina Taherbhoy

 

REVIEWER FOR

Journal of Pharmacology and Experimental Therapeutics

Chinese Journal of Neuroanatomy

Chinese Journal of Anatomy

Acta Acad. Medi. Shanghai

Acta Acad. Medi. Nantong

 

 

PATENT AND INVENTION

Lu L, Gu XS, Dai JJ, Lu SL, Cao Z, Zhang PY, Xu HJ, Tang XL: Liquid of brain cells activation. Bulletin of Patent Invention, 1997, 13(13):16

 

Administration

2005~ present: Member of Molecular Resource Center Internal Advisory Committee at University of Tennessee Health Science Center

2001~ present: Head, Genotyping Core for NIAAA Integrative Neuroscience Initiative Alcoholism

1994-1998: Director of the Department of Histology & Embryology, Nantong Medical College

1994-1998: Tenure review committee member of Nantong Medical College

 

ORIGINAL PAPERS

1.     Wang HR, Lu L, Tang PZ, Tong BY, Gu HY: Scanning electron microscopy of the cerebellum of the newborn rat in tissue culture.  Acta Acad. Medi. Shanghai, 1986,13:455-457

2.     Lu L, Wang HR, Gu HY, Chen LL, Shen XY,Tong BY: Immuno-histochmical observation of rat cerebellar granule cells in tissue culture. Acta Acad. Medi. Shanghai, 1987,14:89-92

3.     Yang YQ, Gu HY, Lu L, Wang HR: Differentiation of neuron-specific enolasse positive cells in the rat submandibular gland.  Acta Acad. Medi. Shanghai, 1989,16:265-268

4.     Yang YQ, Lu L, Gu HY, Wang HR: The neuroendocrine cells in submandibular gland -- a preliminary observation.  Chinese J. Anatomy, 1990, 13:15-18

5.     Feng LY, Lu L, Tong BY, Zhou L, Gu HY: Improvement of method to make rat model of Parkinson' disease.  Acta Acad. Medi.  Shanghai, 1990, 17:160

6.     Tian ML, Lu L, Xu HJ, Wu YM: Viability observation of rat mesencephalic dopaminergic neurons in different nutrient solution.  Acta Acad. Medi. Nantong, 1992,12:164-165

7.     Lu L, Xu HJ, Wu YM, Tian ML: Laminin promotes growth and development of embryonic mesencephalic dopaminergic neurons in vitro. Chinese J. Neuroanatomy, 1992,8: 42-46

8.     Lu L, Xu HJ, Wu YM, Tian ML: Effects of striatal cell on morphological development of mesencephalic dopaminergic neurons in vitro. Chinese J. Anatomy, 1992,15:341-345

9.     Lu L, Xu HJ, Wu YM, Tian ML: Morphological observation of rat mesencephalic dopaminergic neurons in long-term culture. Chinese J Neuroanatomy, 1992, 8:250-254

10.  Lu L, Xu HJ, Wu YM, Tian ML: Study on MPTP toxicity for rat mesencephalic dopaminergic neurons in culture. Acta Acad. Medi. Nantong, 1994,14:127-130

11.  Lu L, Xu HJ, Wu YM, Tian ML: Protective effects of ganglioside GM1 on MPTP damaged dopaminergic neurons of rat in vitro. Chinese J. Neuroanatomy,1994, 10:33-38

12.  Li XY, Lu L: Study in fibronectin of lung cancerous tissue by immuno- histochemical method. Acta Acad. Medi. Nantong, 1994,14:135-137

13.  Gu J, Lu L: Study on affected factors of making enzyme labeled antibody detecting PAIg. Acta Acad. Medi. Nantong, 1994,14:248-249

14.  Cao Z, Lu L, Ding F, Gu J, Liu F, Ying DM, Gu XS: Purification and its application of the digoxigenin labeled human b-NGF DNA probe. Chinese J Neuroscience, 1995,2:141-144

15.  Feng JS, Xu HJ, Wu YM, Huang Z, Lu GM, Lu L: The changes of astrocytes during intracerebral transplantation.  Chinese J. Neuroanatomy, 1995,11:185-189

16.  Tian ML, Lu L, Xu HJ: Study on cholinergic neurons in vitro by histochemical method of acetylcholine. Acta Acad. Medi. Nantong, 1996,16:149-150 

17.  Chen YS, Xu HJ, Wu YM, Lu L: The effect of ganglioside GM1 on MPTP-treated mice. Chinese J. Anatomy, 1996,19:133-137

18.  Cao Z, Lu L, Ding F, Hu YQ, Gu XS: Relationship between levels of NGF mRNA and maturation and functions of testis spermatogenic cell.  Chinese J. Andrology, 1996,10:136-140

19.  Lu L, Cao Z, Ding F, Gu J, Gu XS, Wang JZ, Yu YK, Fan M: Preparation of human bNGF DNA probe labeled with digoxigenin and expression of NGF gene in mouse submandibular gland.  Chinese J. Histochemistry and Cytochemistry, 1997,6:346-351

20.  Lu L, Ding F, Cao Z, Gu J, Gu XS: Detection of NGF mRNA in submandibular gland of female mouse by in situ hybridization method. Acta Acad. Medi. Nantong, 1997,17:147-149

21.  Cao Z, Lu L, Ding F, Yao Denbin,Ying  DM, Gu XS: Preparation and application of the dig-NGF cDNA probe.  Acta Acad. Medi. Nantong, 1997,17:150-151

22.  Gu P, Gu J, Lu L: Study of anticardiolipin antibodies in rheumatoid arthritis. Acta Acad. Medi. Nantong, 1997,17:183-184

23.  Lu L, Ding F, Cao Z, Gu J, Gu XS: Sex difference of NGF gene expression in submandibular gland of mice.  Chinese J. Anatomy, 1998, 21:233-236

24.  Lu L, Ding F, Cao Z, Gu J, Gu XS, Wang JZ, Fan M: Nerve growth factor gene expression in submandibular gland of mice during postnatal development.  Acta Anatomica Sinica, 1998,29:284-288

25.  Lu L, Ding F, Cao Z, Gu J, Gu XS: The study on the NGF gene expression in epididymis of mice.  Chinese J. Family Planning, 1998,7:301-303

26.  Gu J, Lu L, Wu FY, Chen XF, Ding F, Cao Z, Gu XS: Detection of NGF gene expression in human bone marrow by in situ hybridization method.  Acta Acad. Medi. Nantong, 1998,18:147-149

27.  Lu L, Cao Z, Ding F, Gu XS, Gu J, Chen XF, Wu FY: Gene expression of nerve growth factor during development of megalocaryocytes in human bone marrow. Chinese J. Anatomy, 1999, 22:205-207

28.  Ding F, Lu L, Cao Z, Zhong QQ, Gu XS: The effects of lead poisoning on expression of nerve growth factor gene of submandibular gland in mice.  Chinese J Preventive Medicine, 1999, 33:266-268

29.  Ding F, Lu L, Cao Z, Gu XS, Wang JZ, Yu YK, Fang M: The influence of NGF mRNA in submandibular gland in mouse poisoned by lead. Modern Preventive Medicine, 1999,26:291-292

30.  Williams RW, Airey DC, Kulkarni A, Zhou GM, Lu L: Genetic dissection of olfactory bulbs of mice: QTLs on four chromosomes modulate bulb size. Behavioral Genetics, 2001, 133:61-77

31.  Lu L, Airey DC, Williams RW: Complex trait analysis of the hippocampus: Mapping and biometric analysis of two novel gene loci with specific effects on hippocampal structure in mice. Journal of Neuroscience, 2001, 21:3503-3514

32.  Airey DC, Lu L, Williams RW: Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture. Journal of Neuroscience, 2001, 21:5099-5109

33.  Hardy CL, Lu L, Nguyen P, Woodland DL, Williams RW, Blackman MA: Identification of quantitative trait loci controlling activation of TRBV4 CD8+ T cells during murine herpes virus-induced infectious mononucleosis. Immunogenetics, 2001, 53: 395-400

34.  Williams RW, Gu J, Qi SH, and Lu L: The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. Genome Biology 2001, 2(11): research 0046.1-0046.18

35.  Lu L, Mei DF, Gustain DE, Zwas D, Homma S, Yi GH, Wang J: Exercise training normalized altered calcium handling proteins during development of heart failure. J Appl Physiology 2002, 92:1524-1530.

36.  Gu J, Lu L, Xu HR, Chen XF: Plasma thrombopoietin levels in patients with aplastic anaemia and idiopathic thrombocytopenic purpura. Chinese J. Medicine 2002, 115(7):983-987

37.  Airey DC, Lu L, Shou SS, Williams RW: Genetic sources of individual differences in the cerebellum. The Cerebellum, 2002, 1:233-240.

38.  Lu L, Cook R, Gu J, Williams RW, Smeyne RJ: Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Molecular Brain Research 2003, 110(2): 279-88.

39.  Hitzemann R, Hitzemann B, Rivera S, Gatley J, Thanos P, Lu L, Shou S, and Williams R: Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: genetic relationships to alcohol and other drug associated phenotypes. Alcoholism: Clinical and Experimental Research 2003; 27(1):1-11

40.  Peirce J, Chesler EC, Williams RW, Lu L: Genetic architecture of the mouse hippocampus: Identification of gene loci with regional effects. Genes, Brain and Behavior, 2003,2:238-252.

41.  Chesler EJ, Wang J, Lu L, Qu Y, Manly KF, Williams RW: Genetic Correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes. Neuroinformatic 2003; 1(4): 343-357.

42.  Abiola O, É, Lu L, É, Zou F: The nature and identification of quantitative trait loci: a communityÕs view. Nature Genetics 2003;4:911-916.

43.  Hsu HC, Zhang HG, Li L, Yi N, Yang PA, Wu Q, Zhou J, Sun S, Xu X, Yang X, Lu L, Van Zant G, Williams RW, Allison DB, Mountz JD: Age-related thymic involution in C57BL/6J X DBA/2J recombinant inbred mice maps to mouse chromosomes 9 and 10. Genes and Immunity, 2003, 4(6): 402-410.

44.  Seecharan DJ, Kulkarni AL, Lu L, Rosen GD, Williams RW: Genetic control of interconnected neuronal populations in the mouse primary visual system. Journal of Neuroscience, 2003, 23: 11178-11188.

45.  Churchill GA,É., Lu L, É Zou F: The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics 2004, 36(11):1133-7

46.  Williams RW, Bennett B, Lu L, Gu J, DeFries JC, Carosone-Link PJ, Rikke BA, Belknap JK and Johnson TE: Genetic Structure of the LXS Panel of Recombinant Inbred Mouse Strains: A Powerful Resource for Complex Trait Analysis. Mammalian Genome, 2004, 15(8):637-647.

47.  Lu L, Peirce JL, Gu J, Silver LM, Williams RW: A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genetics 2004, 5(1):7

48.  Jablonski MM, Lu L, Wang XF, Chesler EJ, Carps E, Qi SH, Gu J, Williams RW: The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near cadherin 1. Molecular Vision 2004, 10:577-87

49.  Tan XL, Zhou Y, Cai KF, Shao YX, Zhu SX, Lu L, Williams RW, Gu XS: Identification of QTLs for weight and cross-sectional area on cervical enlargement of spinal cord in mice. Yi Chuan Xue Bao. 2004 Aug;31(8):801-6.

50.  Chesler EJ, Lu L, Wang J, Williams RW, Manly KF: WebQTL: Rapid Exploratory Analysis of Gene Expression and Genetic Networks for Brain and Behavior. Nature Neuroscience, 2004, 7(5): 485-486.

51.  Lu L, Chesler EL, Shou S, Qu Y, Gu J, Wang J, Hsu H, Mountz JD, Baldwin N, Langston MA, Hogenesch JB, Threadgill DW, Manly KF, Williams RW: Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nature Genetics 2005, 37(3):233-42.

52.  Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher MT, Wiltshire T, Su AI, Vellenga E, Wang J, Manly KF, Lu L, Chesler EJ, Alberts R, Jansen RC, Williams RW, Cooke MP, de Haan G: Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nature Genetics 2005, 37(3):225-32.

53.  Mountz JD, Yang PA, Wu Q, Zhou J, Tousson A, Fitgerald A, Allen J, Wang X, Cartner S, Grizzle WE, Yi N, Lu L, Williams RW, and Hsu HC: Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in BXD2 recombinant inbred strain of mice.  Scandanavian Journal of Immunology 2005,61(2):128-38.

54.  Zou F, Gelfond J, Airey DC, Lu L, Manly KF, Williams RW, and Threadgill DW: Extending the power of quantitative trait locus analysis using recombinant inbred lines through recombinant inbred intercrosses (RIX): theoretical and empirical considerations. Genetics, 2005, 170(3):

55.  Li HQ, Lu L, Manly KF, Wang J, Zhou M, Williams RW, Cui Y: Inferring gene transcriptional modulatory relations: a genetical genomics approach. Human Molecular Genetics, 2005, 14(9): 1119-1125.

56.  Tsaih, SW, Lu L, Airey DC, Williams RW, Churchill GA: Quantitative trait mapping in a diallel cross of recombinant inbred lines. Mammalian Genome, 2005, 16:344-355

57.  Jablonski MM, Dalke C, Wang XF, Lu L, Manly K, Pretsch W, Pardue M, Rinchik, Williams RW, Goldowitz D, Graw J: An ENU-induced mutation in Rs1h causes disruption of retinal structure and function. Molecular Vision, 2005,11:569-81.

58.  Matthews DB, Bhave SV, Belknap JK, Brittingham C, Chesler EJ, Hitzemann RJ, Hoffmann PL, Lu L, McWeeney S, Miles MF, Tabakoff B, Williams RW: Complex Genetics of Interactions of Alcohol and CNS Function and Behavior. Alcohol Clin Exp Res, 2005 Sep;29(9):1706-1719

59.  Bennett B, Carosone-Link PJ, Lu L, Chesler EJ, Johnson TE: Genetics of body weight in the LXS recombinant inbred mouse strains. Mammalian Genome, 2005 Oct 16(10):764-74

60.  Vazquez-Chona FR, Khan AN, Chan CK, Moore AN, Dash PK, Rosario Hernandez R, Lu L, Chesler EJ, Manly KF, Williams RW, Geisert Jr EE: Genetic networks controlling retinal injury. Molecular Vision, 2005, 11:958-970.

61.  Li CX, Wei X, Lu L, Peirce JL, Williams RW, Waters RS: Genetic Analysis of Barrel Field Size in the First Somatosensory Area (SI) in Inbred and Recombinant Inbred Strains of Mice. Somatosensory and Motor Research, 2005, 22:141-150.

62.  Jablonski MM, Wang XF, Lu L, Miller DR, Rinchik EM, Williams RW, Goldowitz D: The Tennessee Mouse Genome Consortium: Identification of Ocular Mutants. Visual Neuroscience, 2005, 22(5):595-604

63.  Kempermann G, Chesler EJ, Lu L, Lein E, Nathanson J, Williams RW, Gage FH: Natural variation and genetic covariance in adult hippocampal neurogenesis. Proc Natl Acad Sci USA, 2006, 103(3):780-5

64.  Li HQ, Chen H, Bao L, Manly KF, Chesler EJ, Lu L, Wang J, Zhou M, Williams RW, Cui Y: Integrative Genetic Analysis of Transcription Modules: Towards Filling the Gap between Genetic Loci and Inherited Traits. Human Molecular Genetics, 2006,15(3):481-92

65.  Bao L, Wei L. Peirce JL, Homayouni R, Li H, Zhou M, Chen H, Lu L, Williams RW, Pfeffer LM, Goldowitz D, Cui Y: Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relations. Mammalian Genome, 2006, 17(6):575-583.

66.  Peirce JL, Li H, Wang J, Manly KF, Hitzemann RJ, Belknap JK, Rosen GD, Sutter TR, Williams RW, Lu L: How replicable are mRNA expression QTLs? Mammalian Genome, 2006, 17(6):643-656.

67.  Martin M, Dong H, Vallera D, Lee D, Lu L, Williams RW, Rosen GD, Cheverud J, Csernansky J: Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Genes, Brain and Behavior, 2006, 5:614–623

68.  Mozhui K, Hamre KM, Holmes A, Lu L, Williams RW: Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Behavior Genetics, 2007, 37:223–243

69.  Bao L, Zhou M, Ligang Wu, Lu L, Goldowitz D, Williams RW, Cui Y: PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits. Nucleic Acids Research, 2007 Jan;35(Database issue):D51-4.

70.  Bao L, Peirce JL, Lu L, Zhou M, Li H, Goldowitz D, Williams RW, Cui Y: An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes. Human Molecular Genetics, 2007, 16(11):1381-90.

71.  Gatti D, Maki A, Chesler EJ, Kosyk O, Kirova R, Lu L, Manly KF, Qu Y, Williams RW, Perkins A, Langston ME, Threadgill DW, Rusyn I: Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology, 2007, 46(2):548-57.

72.  Dong H, Martin M, Colvin J, Ali Z, Borek J, Wang L, Lu L, Williams RW, Rosen GD, Csernansky JG, Cheverud J: Quantitative trait loci linked to thalamic and cortical gray matter volumes in BXD recombinant inbred mice: implications for the genetics of schizophrenia. Heredity, 2007, 99(1):1381-90

73.  Miyairi I, Lu L, Tatireddigari A, Madi, OS, Belland RJ, Williams RW, Byrne GI: Recombinant inbred mice facilitate rapid identification of p47GTPases conferring resistance to Chlamydial infection. Journal of Immunology 2007, 179(3):1814-24.

74.  Aziz RK, Kansal R, Abdeltawab NF, Rowe SL, Su Y, Carrigan D, Nooh MM, Attia RR, Brannen C, Gardner LA, Lu L, Williams RW, Kotb M: Susceptibility to severe Streptococcal sepsis: use of a large set of isogenic mouse lines to study genetic and environmental factors.  Genes and Immunity, 2007, 8(5):404-15.

75.  Ding M, Lu L, Toth LA: Microarray gene expression in lung and basal forebrain of uninfected and influenza-infected C57BL/6J and BALB/cByJ. Genes, Brain and Behavior, 2007, Aug13.

76.  Peirce JL, Broman KW, Lu L, Williams RW: A simple method for combining QTL maps multiple crosses and experimental designs. Plos ONE 2007, 2(10):e1036

77.  Olsen C, Huang Y, Goodwin S, Ciobanu D, Lu L, Sutter T, Winder D: Microarray Analysis Reveals Distinctive Signaling Between the Bed Nucleus of the Stria Terminalis, Nucleus Accumbens, and Dorsal Striatum. Physiological Genomics 2007 (in press)

78.  V‡zquez-Chona FR, Lu L, Williams RW, Geisert EE: Genomic Loci Modulating the Retinal Transcriptome in Wound Healing. GRSB 2007 (in press)

79.  Jan T, Lu L, Li C, Williams RW, Waters RS: Genetic analysis of posterior medial barrel subfield (PMBSF) size in somatosensory cortex (SI) in recombinant inbred strains of mice. BMC Neuroscience 2008, 9:3 doi:10.1186/1471-2202-9-3

80.   Carneiro AM, Airey DC, Thompson B, Zhu C, Lu L, Blakely R: Functional Coding Variation in the Murine Serotonin Transporter Associated with Anxiety and Alcohol Consumption Traits. Proc Natl Acad Sci USA, 2007 (in review)

81.  Dong H, Yuede C, Coughlan C, Lewis B, Lu L, Williams RW, Csernansky JG: Neuroprotective and neurotoxic effects of memantine in the Tg2576 mouse model of AlzheimerÕs disease. Neuropsychopharmacology, 2007 (in review)

82.  Peirce JL, Broman KW, Lu L, Chesler EJ, Zhou G, Airey DC, Birmingham AE, Williams RW: A permutation method for quantitative analysis of expanded advanced intercross populations. BMC Genetics 2007 (in review)

 

BOOK CHAPTERS

1.     Hsu HC, Lu L, Yi N, Zant  GV, Williams RW, Mountz JD: Quantitative Trait Loci (QTL) Mapping in Aging Systems for METHODS IN MOLECULAR BIOLOGY (Biological Aging:  Methods and Protocols), Humana Press, Totowa, New Jersey, 2007, 371:321-48

 

ABSTRACTS OF INTERNATIONAL MEETING

1.     Lu L, Xu HJ, Wu YM, Tian ML: Effects of laminin, gangliside GM1, and 1-Methyl-4-phonyl-1,2,3,6-tetrahydropyridine (MPTP) on growth and development of mesencephalic dopamenergic neurons in vitro. The 2nd International Conference on Anatomical Sciences, Beijing China, October 12-15,1992

2.     Wu YM, Lu L, Xu HJ, Tian ML: Effects of laminin on growth and development of mesencephalic dopamenergic neurons in vitro and in vivo. The 2nd International Conference on Anatomical Sciences, Beijing, China, October 12-15, 1992

3.     Lu L, Cao Z, Gu J, Ding F, Gu XS: Expression of the nerve growth factor gene in submandibular gland, testis and bone marrow. The 10th International Congress on Histochemistry and Cytochemistry, Kyoto, Japan, August 18-23, 1996

4.     Lu L, Airey DC, Gillissen E, Zhou GM, Williams RW: New murine hippocampus-specific QTL maps to distal Chr 1. The 13th International Mouse Genome Conference. Philadelphia, USA, October 31-November 3, 1999

5.     Airey DC, Lu L, Strom R, Gillissen E, Zhou GM, Williams RW: Cerebellum-specific QTLs in the mouse brain. The 13th International Mouse Genome Conference, Philadelphia, USA, October 31-November 3, 1999

6.     Lu L, Airey DC, Williams RW: Complex trait analysis of the mouse hippocampus. The 30th Neuroscience Meeting, New Orleans, USA, November 4-9, 2000

7.     Airey DC, Lu L, Williams RW: Gene loci for mouse cerebellum and internal granule layer size. The 30th Neuroscience Meeting, New Orleans, USA, November 4-9, 2000

8.     Williams RW, Kulkarni A, L Jones, Zhou GM, Airey DC, Lu L: Growth of the olfactory bulbs is modulated by QTLs on chromosomes 4,6,11 and 17. The 30th Neuroscience Meeting, New Orleans, USA, November 4-9, 2000

9.     Ding F, Cao Z, Lu L, Gu XS: Effects of lead exposure on transcription of nerve growth factor mRNA and cell growth of the submandibular gland of mice. The 30th Neuroscience Meeting, New Orleans, USA, November 4-9, 2000

10.  Rosen GD, Williams AG, Capra JA, Connolly MT, Cruz B, Lu L, Airay DC, Kulkarni A, Williams RW: The mouse brain library. The 14th International Mouse Genome Conference, Narita, Japan, November 6-10, 2000

11.  Williams RW, Threadgill DW, Airey DC, Gu J, Lu L: RIX Mapping: A demonstration using CXB RIX hybrids to map QTLs modulating brain weight in mice. The 31th Neuroscience Meeting, San Diego, USA, November 10-15, 2001.

12.  Threadgill DW, Airey DC, Lu L, Manly K, Williams RW: Recombinant inbred intercross mapping: a new approach to extend the power of existing mouse resources. The 15th International Mouse Genome Conference, Edinburgh, Scotland, October 21-24, 2001.

13.  Shou S, Lu L, Williams RW: Transcriptome chromosome maps: a novel resource for complex trait analysis of the mouse CNS. The 4th Annual Meeting of the International Behavioural and Neural Genetics Society, San Diego, USA, November 8-10, 2001

14.  Williams RW, Threadgill DW, Manly KF, Rosen GD, Shou S, Airey DC, Gu J, Lu L: Integrated complex trait analysis of brain and behavior in mouse: near-term prospects for high-resolution QTL mapping using large RI and RIX sets. The 4th Annual Meeting of the International Behavioural and Neural Genetics Society, San Diego, USA, November 8-10, 2001

15.  Lu L, Airey DC, Rosen GD, Williams RW: Gemetic dissection of the mouse hippocampus: Mapping quatitative trait loci with selective and regional effects. International conference on neuroregeneration (ICN), Nantong, China, September 21-24, 2001

16.  Williams RW, Lu L, Wang XF, Qi S, Gu J, Jablonski MM: Mapping and initial characterization of a spontaneous mutation affecting lens development in RIIIS/J inbred mice. The ARVO 2002 Annual Meeting, Ft Lauderdale, Florida, USA, May 4 - 9, 2002

17.  Watson R, Koratkar R, Lu L, Gu J, Finegan AA, Margan JL, Guz J, Williams RW, Siracusa LD: Expansion of the BXH RI series: derivation and characterization of three new BXH recombinant inbred lines and one new BXH recombinant congenic line. Abst Amer Assoc Cancer Res 2002.

18.  Peirce JL, Lu L, Zhou G, Silver LM, and Williams RW: Generation and Characterization of Highly Recombinant Inbred Lines from an Advanced Intercross. 1st Annual Complex Trait Consortium (CTC) Meeting, Memphis, USA, May 15-17, 2002.

19.  Hsu HC, Huang-Ge Zhang HG, Li L, Mullinax C, Lu L, Zant GV, Williams RW, Allison DB, Mountz JD: Age-related Thymic Involution in C57BL/6J X DBA/2J Recombinant Inbred Mice Fits A Negative Exponential Regression Model and Maps to Mouse Chromosome 9. 1st Annual Complex Trait Consortium (CTC) Meeting, Memphis, USA, May 15-17, 2002.

20.  Lu L, Gu J, Qi SH, Airey DC, Rosen GD, Peirce J, Robert W. Williams RW, Zhou G: Analysis of a tenth generation advanced intercross and a new set of ~45 derivative BXD recombinant inbred strains. 1st Annual Complex Trait Consortium (CTC) Meeting, Memphis, USA, May 15-17, 2002.

21.  Threadgill D, Airey DC, Lu L, Manly KF, Williams RW: Genetic control of stochastic variation revealed by recombinant inbred intercross (RIX) mapping. 1st Annual Complex Trait Consortium (CTC) Meeting, Memphis, USA, May 15-17, 2002.

22.  Williams RW, Shou S, Lu L, Qu Y, Wang J, Manly K, Chesler E, Hsu HC, Mountz J, Threadgill D: Genomic Analysis of Transcriptional Networks: Combining Microarrays with Complex Trait Analysis. 1st Annual Complex Trait Consortium (CTC) Meeting, Memphis, USA, May 15-17, 2002.

23.  Lu L, Shou S, Qu YH, Manly K, Chesler E, Hsu HC, Mountz J, Threadgill D, Williams RW: Genomic Analysis of Transcriptional Networks: Combining Microarrays with Complex Trait Analysis. 2002 Southeast Regional Meeting of the Society for Developmental Biology, Gatlinburg, Tennessee, May 29-31,2002

24.  Shou S, Lu L, Qu Y, Jensen P, Williams RW (2002) High transcriptional diversity and complexity among mouse brain regions. The 32th Neuroscience Meeting, Orlando, USA, November 2-7 2002.

25.  Williams RW, Shou S, Qu YH, , Chesler E, Manly K, Wang J, Hsu HC, Mountz J, Threadgill D, Lu L: Massively parallel mapping of transcriptional networks. The 32th Neuroscience Meeting, Orlando, USA, November 2-7 2002.

26.  Tong Y, Deaton J, Lu L, Williams RW, Goldowitz D: Mapping of the hippocampal lamination defect gene, HLD, in the mouse. The 32th Neuroscience Meeting, Orlando, USA, November 2-7 2002.

27.  Lu L, Airey DC, Gu J, Zhou GM, Williams RW; Genetic architecture of the mouse hippocampus: Confirmation of gene loci with advanced intercross progeny. The 32th Neuroscience Meeting, Orlando, USA, November 2-7 2002.

28.  Smeyne RJ, Tharp R, Smeyne M, Lu L, Williams RW: Identification of quantitative trait loci for susceptibility to MPTP in an animal model of Parkinsons disease. The 32th Neuroscience Meeting, Orlando, USA, November 2-7 2002.

29.  Chesler EJ, Shou S, Qu Y, Yang X, Lu L, Williams RW: Microarray analysis of sex differences in the mouse CNS transcriptome. The 32th Neuroscience Meeting, Orlando, USA, November 2-7 2002.

30.  Jabblonski MM, Wang XF, Lu L, Goldowitz D, Willliams RW, Tennessee Mouse Genome Consortium: Regional mutagenesis of the mouse genome: Ocular phenotypes. The 32th Neuroscience Meeting, Orlando, USA, November 2-7 2002.

31.  Williams RW, Manly KF,  Shou S,  Chesler EJ,  Hsu HC,  Mountz J, Threadgill DW, Lu L: Massively parallel complex trait analysis of transcriptional activity in mouse brain. The 16th International Mouse Genome Conference, San Antonio, Texas, November 17-20, 2002.

32.  Lu L, Gu J,  Threadgill D,  Williams R: Complex trait analysis of mice hippocampus using CXB RIX mapping method. The 16th International Mouse Genome Conference, San Antonio, Texas, November 17-20, 2002.

33.  Manly KF, Wang J, Shou S. Qu Y, Chesler E, Lu L, Hsu HC, Mountz JD, Threadgill D, Williams RW (2002) QTL mapping with microarray expression data. The 16th International Mouse Genome Conference, San Antonio, Texas, November 17-20, 2002.

34.  Williams RW, Lu L, Qu YH, Wang JT, Chesler EJ, Hsu HC, Mountz JD, Threadgill DW, Manly KF: Brain Transcriptional Control Networks. Fourteenth Annual Spring Brain Conference, Radisson Poco Diablo Resort in Sedona, Arizona, USA, March 12-15, 2003.

35.  Geisert EE, Vazquez-Chona F, Lu L, Chesler EJ, Williams RW: The control of gene expression following injury in the rat retina: QTL and PCA. The ARVO 2003 Annual Meeting, Ft Lauderdale, Florida, USA, May 4 - 9, 2003.

36.  Williams RW, Xu JL, Zhai HT, Lu L: Complex trait analysis of mouse retinal horizontal cell number. The ARVO 2003 Annual Meeting, Ft Lauderdale, Florida, USA, May 4 - 9, 2003.

37.  Jablonski MM, Wang XF, Lu L, Pardue M, Iannaccone A, Goldowitz D, William RW: Regional Mutagenesis of the Mouse Genome: An Update of Ocular Phenotypes. The ARVO 2003 Annual Meeting, Ft Lauderdale, Florida, USA, May 4 - 9, 2003.

38.  Chesler EJ, Wang JT, Lu L, Peirce JL, Manly KF, Williams RW: Web-based QTL mapping and genetic correlation analysis of gene expression and alcohol-related traits in BXD strains. Research Society for Alcoholism 26th Annual meeting, Ft Lauderdale, Florida, USA, June 21-25, 2003.

39.  De Koning DJ, Carlborg O, Williams RW, Lu L, Haley C (2003) Epistatic QTL for gene expression in mice: potential for BXD expression data. The 2nd Annual Complex Trait Consortium (CTC) Meeting, Oxford, UK, July 1-3, 2003.

40.  Chesler EJ, Wang JT, Lu L, Qu, Y, Manly K, 1Williams RW: Genetic correlations and associative networks for CNS transcript abundance and neurobehavioral phenotypes in a recombinant inbred mapping panel. The 2nd Annual Complex Trait Consortium (CTC) Meeting, Oxford, UK, July 1-3, 2003

41.  Chesler, E.J., Wang, J., Lu, L., Peirce, J.L., Qu, Y., Manly, K.F., Williams, R.W., (2003) Web-based QTL mapping and genetic correlation analysis of gene expression and alcohol-related traits in BXD strains. Alc. Clin. Exp Res. Supplement 27(5):125A.

42.  Lu L, Chesler EJ, Chen H, Li Y, Cui Y, Sharp BM, Wang JT, Manly K, Williams RW: Genomic Analysis of Gene Interaction In Mice Forebrain. The 2nd Annual Complex Trait Consortium (CTC) Meeting, Oxford, UK, July 1-3, 2003

43.  Osadchuk AV, Airey DC, Lu L, Threadgill DW, Williams RW: A novel appr