Strain Means

Select strain type to view summary data on the retinal ganglion cell population of several different types of mice
Standard Inbred Mice
These are genetically homozygous and fully inbred strains. Variation within an inbred strain is due to environmental effects and developmental noise. No systematic effort was taken to minimize environmental differences. Animals are of mixed sexes and ages.
F1 Inbred Mice
The F1 hybrids are heterozygous at many gene loci, but members of a given cross are also genetically identical. Consequently, variation among members of a particular cross is environmental in origin. The F1's were generated by a cross between a low and a high cell number strain. The MidPar column is the midpoint between the low and the high strain. Maternal effect can be assessed by comparing reciprocal F1 crosses.
Recombinant Inbred Strains
Recombinant inbred strains are often used for mapping QTLs. We have strain data for two RI sets, BXD and BXH. The BXD set was generated from an outcross between the parental strains C57BL/6J and DBA/2J, and the BXH set was generated from an outcross between C3H and DBA/2J.
Genetically Heterogeneous Strains
These are outcrossed or randomly-bred strains of mice. Variation in these strains is primarily the sum of environmental factors and genetic differences.
Wild Inbred Strains
These are inbred strains of mice derived from several different species of mice. Standard inbred mice were probably derived from a cross between Mus domesticus and Mus molossinus. The lineages of some of these species diverged more than 2 million years ago.
Interspecies F1, F2, and N2 backcross progeny
Interspecies crosses are often used to estimate numbers of genes affecting a quantitative trait and in mapping genes and QTLs. We have crossed CAST/Ei with BALB/c.

Abbreviations used in tables:

RGCs = retinal ganglion cells
SEM = standard error of the mean
SD = standard deviation
CofV = coefficient of variation (mean/SD)
CI- = lower 95% confidence interval
CI+ = upper 95% confidence interval
Z = normal score
Z_Exp = excepted Z score for the nth ranked member of set, Type=notes of genotype or species..

Summary Data on the Retinal Ganglion Cell Population in Strains of Mice

Version of Feb 2, 1996
Robert W. Williams, Richelle C. Strom, Dennis S. Rice, and Dan Goldowitz
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With thanks to R. Cushing, S. Smith, B. Taylor, M. Davisson, and T. K. Hurt

number of independent samples763
number of individuals counted573
number of cases, category 1540
number of cases included in first set of studies451
number of types of mice62
number of standard inbred strains17
number of F1 cross types5
number of BXD strains26
number of BXH strains12
number of wild inbred strains7
number of non-inbred strains3
number of N2 types2
number of other strains2
number of duplicate counts146
number of R vs L nerve comparisons in study19