Project 1: The Mouse Brain Library Project 2: Internet Microscopy (iScope) Project 3: Neurocartographer and Segmentation of the MBL Project 4: The Neurogenetics Tool Box


















Principal Investigator/Program Director Williams,Robert W.


Integrative relationship between brain research and informatics components of the project

Complex trait analysis and QTL mapping are data-intensive tasks. To establish the genetic and environmental basis of morphometric differences among genetically defined mice, a huge number of brains must be examined. Efficient exploitation of an image warehouse like the MBL cannot occur without efficient and effective informatics solutions. This project will extract quantitative CNS traits from brains in the MBL. These numbers will be a far more succinct and usable representation of the MBL. These quantitative traits will then be the “deliverables” sent from the NeuroCartographer Project to the Neurogenetics Tool Box. These numbers will also be fed back to the MBL to provide far more powerful navigational tools than would otherwise be available. It will be possible to issue a command in the MBL that is equivalent to  “Display sections of the anterior thalamic nuclear complex of male mice between the ages of 200 and 300 days in these 10 strains.” It will also be possible to issue a command to the iScope such as “Acquire through-focus series for stereological analysis (gray scale please) of the lateral habenula on both right and left sides of a sample of the first 100 advanced intercross progeny in the MBL.” All of these powerful new tools rely on advanced segmentation protocols to digitally dissect the MBL collection.



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