Project 1: The Mouse Brain Library Project 2: Internet Microscopy (iScope) Project 3: Neurocartographer and Segmentation of the MBL Project 4: The Neurogenetics Tool Box


















Principal Investigator/Program Director Williams,Robert W.


Means of assessing success with respect to Phase II objectives

One major objective of Phase II is to refine neuroinformatics tools. The central feature in this project is the use of a standard coordinate system to provide database access to anatomical images in the MBL. BrainMap is a well-developed database built around this idea. Our contribution will be a substantial refinement in accuracy, the development of new web-based software with a powerful user interface, and a new application setting.

  As a neuroanatomical database supporting navigation and morphometric investigations at high resolution over the Internet, the MBL breaks new ground. Given the clearly defined need for image warehouses of histological material, we are optimistic that our approach and our software will soon be adopted by other neuroinformatics centers. To support the spread of this technology, all software along with source code will be made freely available. At the Computer Vision Center for Vertebrate Brain Mapping, we have had many years of experience in engineering software for the neuroscience community. The first personal computerbased autoradiographic software was developed at our center (McEachron et al. 1987), and we have been developing sophisticated software for neuroscientists ever since. Applications now run on MacOS, UNIX, and Windows in over 300 laboratories worldwide. We have extensive experience not only in software development but also in software testing, support, and documentation (Gustafson 1995, 1997, 1999; Nissanov 1998).



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