Project 1: The Mouse Brain Library Project 2: Internet Microscopy (iScope) Project 3: Neurocartographer and Segmentation of the MBL Project 4: The Neurogenetics Tool Box


















Principal Investigator/Program Director Williams,Robert W.


1. Objective

The Administrative Core will maintain all Core and Project budgets, provide renewal applications, oversee the travel budget and approve travel arrangements as they relate to the program project, and arrange and chair Executive Committee and Core Committee meetings. In addition, the Administrative Core will manage Advisory Board interactions. As chair of the Executive Committee, the Program Director will receive and distribute applications for new projects and will be responsible for new uses of the Core staff and facilities. The Director will review all requests to redistribute funds in the Program budgets and in the budgets of grant or protocol applications that include the use of Program Core units.

  2. Organizational Chart

  See Organizational Chart
The Administrative Core will oversee all aspects of the programs and cores as detailed above. The interactions among the projects are illustrated above. An important part of the program project is the External Advisory Board. This Board will meet as a group each spring in Memphis (funds have been requested to cover travel expenses and a small honorarium). The External Advisory Boards main purpose is to guide and critique plans and our implementation. A secondary goal is to provide us with their insight into new methods and problems that the project as a whole should consider implementing. A senior member of the Human Brain Project will also be invited to participate in the annual review of the PPG.

Members of the board were selected by the PIs of the projects on the basis of their stature in major fields of bioinformatics and neuroscience. At present the board consists of

1.  Adrianne Noe, Director of the National Museum of Health and Medicine in Washington. Dr. Noe is in charge of several major research collections, including the Yakovlev-Hakem Human Brain Collection. She is currently collaborating with Dr. Wally Welker on developing and distributing the Wisconsin Brain Collection, now known as the Brain Biodiversity Project. Dr. Noe brings a great deal of expertise to our PPG pertaining to the organization and long-term maintenance of collections of slides and digital images.

2.  Arthur Toga, Associate Director of the Neuroimaging Center at UCLA. Dr. Toga is one of the worlds leading authorities on brain mapping and imaging. He will be advising us particularly regarding software systems and algorithms used to reconstruct and segment images as part of the NeuroCartographer project.

3.  John Belknap, Professor of Neuroscience, Oregon Health Science Center. Dr. Belknap is one of the foremost experts on complex trait analysis as it pertains to the study CNS structure and function in mice. He is a strong statistician and behavioral neuropharmacologist who has done a great deal to advance the use of recombinant inbred strains in neuroscience. Dr. Belknap brings to this PPG a particular interest in behavioral variation among mice that will provide an excellent counterpoint and complement to our own focus on anatomical variation.

4.  Joel Richardson, Senior Programmer, co-PI of the Mouse Genome Database, Jackson Laboratory, Bar Harbor, Maine. Joel Richardson is the senior database programmer for the Jackson Laboratorys bioinformatics program. He wrote and designed much of the Mouse Genome Database web interface. He has a strong background is large relational and object databases such as Informix and Oracle. He will provide us with criticism and advice as to how best to implement and support our informatics superstructure.

5. Unfilled. We have intentionally left one position free to be filled early in the first year. When this application is reviewed we will reassess what areas would most benefit from an external advisor: robotics, video production, web design, distributed database structure, image warehousing, cell-level image segmentation.

  3. Staffing

Director (Robert W. Williams, 5% effort). The directors functions are as described above. A half-time Administrative Assistant will be responsible for the following duties: (1) assist in scheduling meetings and progress reports, (2) help with database entry and backups, (3) help to prepare/convert documents to html for uploading onto the web, (4) maintain a listing of databases and publications, (5) order supplies[GDR1] , and (6) arrange for all travel specifically related to the PPG; for example Human Brain Project annual meetings, meetings with External Advisory Board members, etc.

4. Resources and Environment

The Administrative Core will be housed in the Department of Anatomy and Neurobiology at the University of Tennessee, Memphis. After renovations of the Neuroscience complex, the Administrative Office will move to the fifth floor of the Wittenborg Building (see Letter from S.T. Kitai, Chair).

As noted in the Introduction, the University of Tennessee, Memphis, has demonstrated a strong commitment to this project, demonstrated by the commitment of funds, space, and equipment.

5. Services provided

The services provided are listed in the Objectives.