Project 1: The Mouse Brain Library Project 2: Internet Microscopy (iScope) Project 3: Neurocartographer and Segmentation of the MBL Project 4: The Neurogenetics Tool Box



















Principal Investigator/Program Director Williams, Robert W.

  Permanence and Maintenance Plan: Phase 2  
  We recognize that maintenance is a serious problem, particularly with volatile web-based resources. The issue of permanence is taken up particularly in Project 2. This is one of the main reasons that we have asked Dr. A. Noe, Director of the National Museum of Health and Medicine, to join our External Advisory Board (p. 150). We have also gone to the effort to obtain a domain name for our bioinformatics effort that is independent of any particular research institution (<>). Thus, our resources will be permanently available at this URL regardless of long-term institutional affiliations of our members. This domain can accommodate and a tremendous amount of growth and will be able to host other neuroinformatics sites.

Internet publishing and archiving is now advancing rapidly (e.g., BioMed Central), and it seems probable that large and well-endowed organizations other than NIH will soon be equipped to handle, archive, and mirror sites such as <>. We also hope to collaborate with other neuroinformatics groups interested in the mouse CNS. This is one reason we are so pleased that Dr. Toga has been able to join our External Advisory Board, since he is the principal investigator of a newly funded Mouse Brain Mapping Project (letter p. 152) that will complement our own work by studying developmental changes in the CNS of several strains of mice.
  Evaluation Plan  
  Introduction to the Application  
  Informatics Center for Mouse Neurogenetics (HBP)  
  Investigating Genetic Variation  
  Generic Resources versus Specific Goals  
  The External Advisory Board  
  Institutional Support for this Program Project