Xusheng Wang, Ph.D. 855 Monroe Avenue Memphis TN, 38163 Email:  xwang39@uthsc.edu Phone:  901-448-1761

EMPLOYMENT                                                                                                                       )

Director	Bioinformatics core, UT Center for Integrative and Translational Genomics, University of Tennessee Health Science Center	2010-present
Research Associate	Department of Anatomy and Neurobiology, University of Tennessee Health Science Center	2008-present

 

ACADEMIC DEGREES                                                                                                            )

Ph.D.	Zhejiang University (China)/University of California, Davis (USA)	2006
M.S.	Zhejiang University (China)/International Rice research Institute (Philippines)	2003
B.S.	Zhejiang University (China)	2000

 

PROFESSIONAL EXPERIENCES                                                                                            )

Research Associate	Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, USA	2008-present
Post-doctoral Fellow	Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, USA	2007-2008
Lecture	Zhejiang University, China	2006-2007
Junior Scientist	Education Aboard Program of University of California, Davis in China (Peking University)	2006-2007
Junior Specialist	University of California, Davis, USA	2005-2006
Visiting Scholar	International Rice Research Institute, Philippine	2002-2003

 

 

RESEARCH INTERESTS                                                                                                          )

.      Systems genetics, complex trait analysis, and functional genomics

.      High-throughput DNA and RNA sequencing

.      Quantitative genetics and Statistical Genomics

.      Control of gene expression

.      Genetics of complex diseases

 

PROFESSIONAL SOCIETIES                                                                                                   )

.         International Complex Trait Consortium

.         International Behavioral and Neural Genetics Society

.         Sigma Xi

.         International Mouse Genome

.         International Human Genetic Society

 

TEACHING EXPERIENCES                                                                                                      )

Biostatistics	Zhejiang University	Spring 2007
Bioinformatics	China Jiliang University (Invited)	Sprint 2007
Bioinformatics	Zhejiang Forest College (Invited)	Sprint 2007
Bioinformatics	University of Tennessee, Health Science Center (Invited)	Spring 2010

 

ACTIVITIES & SERVICES                                                                                                         )

 

President	Graduate Student Union, College of Agriculture and Biotechnology, Zhejiang University	2001-2002
President	Student Union, College of Agriculture and Biotechnology, Zhejiang University	1999-2000

 

INVITED TALKS IN CONFERENCES                                                                                      )

 

High-throughput sequencing of the DBA/2J mouse genome. UT-ORNL-KBRIN Bioinformatics Summit 2010. March 19-21, 2010. Lake Barkley State Resort Park Cadiz, KY.

 

Whole-genome sequence of DBA/2J and its use for reverse complex trait analysis. The 9th annual meeting of the Complex Trait Community. Chicago, IL, USA. May 2010.

 

PUBLICATIONS                                                                                                                      )

1.      Richard M. Bruskiewich, Alexander B. Cosico, William Eusebio, Arllet M. Portugal, Luralyn M. Ramos, Ma. Teresa Reyes, May Ann B. Sallan, Victor Jun M. Ulat, Xusheng Wang, Kenneth L. McNally, Ruaraidh Sackville Hamilton and Christopher Graham McLaren. Linking genotype to phenotype: the International Rice Information System (IRIS). Bioinformatics. 2003; 19 Suppl1:i63-65.  

2.      Xusheng Wang, Xiangqian Zhao, Jun Zhu, Weiren Wu. Genome-wide investigation of intron length polymorphisms and their potential as molecular markers in rice (Oryza sativa L.). DNA Res 2005;12:417-427.  

 

3.      Xusheng Wang, Weiren Wu, Gulei Jin, Jun Zhu. Genome-wide identification of R genes and exploitation of candidate RGA markers in rice. Chinese Science Bulletin. 2005; 50(11):1120-1126.

 

4.      Xusheng Wang, Jun Zhu, Locedie Mansueto and Richard Bruskiewich. Identification of Candidate Genes for Drought Stress Tolerance in Rice by the integration of a genetic (QTL) map with the rice genome physical map. J Zhejiang Univ SCI. 2005; 6B(5):382-388.  

 

5.      Xusheng Wang, Hongbo Zhu, Gulei Jin, Weiren Wu, Jun Zhu. Genome-scaled identification and analysis of LEA genes in rice (Oryza sativa L.). Plant Science. 2007; 172(2): 414-420.

 

6.      Mahmood Qaisar, Zheng Ping, Wu Donglei, Wang Xusheng, Yousaf Hayat, Ul-Islam Ejaz, Hassan Muhammad Jaffar, Jilani Ghulam, Azim Rashid. Prediction of anoxic sulfide biooxidation under various HRTs using artificial neural networks. Biomed Environ Sci 2007;20:398-403.

 

7.      Xusheng Wang, Minghua Zhang, Jun Zhu, Shu Geng. Spectral prediction of Phytophthora infestans infection on tomatoes using artificial neural network (ANN). International Journal of Remote Sensing. 2008; 29:1693-1706.

 

8.      Lu Lu, Lai Wei, Jeremy L Peirce, Xusheng Wang, Jianhua Zhou, Ramin Homayouni, Robert W Williams, and David C Airey. Using gene expression databases for classical trait QTL candidate gene discovery in the BXD recombinant inbred genetic reference population: Mouse forebrain weight. BMC Genomics. 2008, 9: 444.

 

9.      Khyobeni Mozhui, Daniel C. Ciobanu, Thomas Schikorski, Xusheng Wang, Lu Lu, Robert W. Williams. Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression. PLoS Genetics 2008, 4(11): e1000260.  

 

10.  Xusheng Wang, Jiajuan Dai, Ying Chen, Xiaodong Wang, Jun Zhu, Lu Lu. Expression QTL and genetic regulatory network analysis reveals that Gabra2 is involved in the stress response. Stress. 2009; 12(6): 499-506.

 

11.  Xusheng Wang, Qin Shen, Ying Chen, Lingli Xu, Xiaodong Wang, Jun Zhu, Lu Lu. Expression QTL and regulatory network analysis of microtubule-associated protein tau gene. Parkisonism related disorder. 2009; 15(7):525-531. 

 

12.  Eldon E. Geisert, Lu Lu, Natalie E. Freeman-Anderson, Xusheng Wang, Weikuan Gu, Yan Jiao, Robert W. Williams. Large-scale variation in gene expression in the mouse eye: Covariance with ocular and retinal traits. Molecular Vision. 2009; 15:1730-1763.

 

13.  Alice Gerrits, Yang Li, Bruno M. Tesson, Leonid V. Bystrykh, Ellen Weersing, Albertina Ausema, Bert Dontje, Xusheng Wang, Rainer Breitling, Ritsert C. Jansen, Gerald de Haan, Expression quantitative trait loci are highly sensitive to cellular differentiation state. PLoS Genetics. 2009; 5(10): p. e1000692.

 

14.  Xusheng Wang, Ying Chen, Xiaodong Wang, Jun Zhu, Lu Lu. Genetic regulatory network analysis for App based on genetical genomics approach, Experimental Aging Research. 2010. 36(1): 79-93.  

 

15. Daniel C. Ciobanu, Lu Lu, Khyobeni Mozhui, Xusheng Wang, Manjunatha Jagalur, John A. Morris, William L. Taylor, Klaus Dietz, Perikles Simon, Robert W. Williams. Detection, Validation, and downstream analysis of allelic variation in gene expression. Genetics, 2010. 184(1): 119-128.

 

16. Xusheng Wang, Richa Agarwala, John A Capra, Zugen Chen, Deanna M Church, Daniel C Ciobanu, Zhengsheng Li, Lu Lu, Khyobeni Mozhui, Megan K Mulligan, Stanley F Nelson, Katherine S Pollard, Williams L Taylor, Donald B Thomason, Robert W Williams. High-throughput sequencing of the DBA/2J mouse genome. BMC Bioinformatics, 2010. 11(Suppl 4): O7. 
17. Zhengsheng Li, Megan K. Mulligan, Xusheng Wang, Michael F. Miles, Lu Lu, Robert W. Williams. A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among Mice. PLoS One, 2010. 5(8): e12181.
18. Hong Lu, Xusheng Wang, Matthew Pullen, Huaijin Guan, Hui Chen, Shwetapadma Sahu, Bing Zhang, Hao Chen, Robert W. Williams, Eldon E. Geisert, Lu Lu, Monica M. Jablonski. Genetic Dissection of the Gpnmb Network in the Eye. Investigative Ophthalmology & Visual Science, 2011. doi: 10.1167/iovs.10-6493.
19. Patrizia Porcu, Todd K. O'Buckley, Soomin C. Song, Jo Lynne Harenza, Lu Lu, Xusheng Wang, Robert W. Williams, Michael F. Miles, A. Leslie Morrow. Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation. PLoS One, 2011.6(4): e18405.

 

20.  Xusheng Wang, Yan Lu, Jianguo Wu. Determination of oil component in cottonseeds with Near Infrared Reflectance Spectroscopy. Acta Agriculturae Zhejiangensis. 2000; 13(4):218-222.

 

21.  Yusong Xu, Xusheng Wang, Hubin Wang, Chenfu Lou. Cloning and genomic organization of a novel zinc finger portein gene from silkworm, Bombyx mori. CANYE KEXUE. 2005; 30(4):343-347.

 

22.  Gulei Jin, XuSheng Wang, Jun Zhu. Bioinformatic analysis of the 14-3-3 gene family in rice. ACTA Genetica Sinic. 2005; 32(7):726-732.

 

23.  Zhongzhong Chen, Xusheng Wang, Jun Zhu. Analysis of SSRs polymorphism by genome-scale comparing between indica and japonica. Chinese Journal of Rice Science. 2005; 19(4):303-307.

 

24.  Dongliang Yu, Boxiong Zhong, Yan Fu, Xusheng Wang. Comparison of ESTs and SNPs from posterior silkgland of silkworm Bombyx mori between the strain P50 and C108. Canye Kexue. 2005; 31(4): 434-438.

 

25.  Yongquan Lu, Wang Xusheng, Weisu Huang, Tianxia Xiao, Yan Zheng, Weiren Wu. Development of amplified consensus genetic markers in gramineae based on rice intron length polymorphisms. Scientia Agricultura Sinica. 2006; 39(3):433-439.

 

26.  Dong-liang Yu, Xusheng Wang, Fei Xu, Yan Fu. Bioinformatics identification and analysis for Box C/D SnoRNAs in silkworm genome. Scientia Agricultura Sinica. 2007; 40(1):196-203.

 

27.  Tianxia Xiao, Xiangqian Zhao, Xusheng Wang, Weiren Wu, Jun Zhu. Examination and evaluation of PCR-based RGA markers in rice. Journal of Zhejiang University (Agriculture and Life Sciences). 2007; 33(1):51-55.

 

28.  Jiasheng Wu, Xusheng Wang. Methods of bioinformatic analysis for candidate genes underlying quantitative trait loci(QTLs). Journal of Zhejiang Forestry College. 2008; 25:104-108.

 

29.  Jiasheng Wu, Yanhong Zhao, Xusheng Wang. Bioinformatic Analysis of MYB Protein Family in Oryza sativa L.ssp.japonica. Journal of South China Agriculture University. 2009. 30(4): 43-48.

 

30.  Xusheng Wang, Ying Chen. Xiaodong Wang, Lu Lu. Advance in study of gene expression (eQTL). Life Science. 2009; 1: 38-43. 

 

ABSTRACTS of CONFERENCES                                                                                             )

1.      Xusheng Wang, Prashanth G. Bagali, Renáe Lafitte, Zhikang Li, Zhu Jun and Richard Bruskiewich. Identification of Candidate Genes for Drought Stress Tolerance in Rice by the Integration of Genetic (QTL) Maps with the Rice Genome Physical Map. The First International Symposium on Rice Functional Genomics. 2003.

 

2.      Wang Xusheng, Hori RT, Lu Lu, Robert W Williams. Reverse complex trait analysis of transcripts involved in CNS function. The 10th Annual Genes, Brain and Behavior Meeting of IBANGS. 2008.

 

3.      Xusheng Wang, Melloni Cook, Beth Bennett, Lu Lu, Robert Williams. The clock gene, Per3, a candidate gene for ethanol and stress in mice. RSA/ISBRA Joint meeting. 2008.

 

4.      Robert W. Williams, Xusheng Wang, Daniel Ciobanu, Yan Cui, David Li, Kyobenic  Mozhui, Megan Mulligan, Stanley Nelson, William Taylor, Donald Thomason, Evan

G. Williams, Lu Lu. Next-Generation Genomic Resources for the BXD Genetic

Reference Panel. International Meeting on BXD Phenotyping. Braunschweig, Germany November  2009.

 

5.      Lu Lu, Xusheng Wang, Robert W. Williams. Genetic regulation of the expression of GABA-A receptors in mouse brain. The 11th Annual Meeting of the International Behavioural and Neural Genetics Society (IBANGS), Dresden, Germany, June, 2009.

 

6.      Xusheng Wang, Ying Chen, Lu Lu. Preliminary study of expression QTL analysis of candidate genes related to Alzheimer's disease. The 39th Neuroscience Meeting, Chicago, Illinois, USA, October, 2009.

 

7.      Megan K. Mulligan, Xusheng Wang, Lu Lu, Robert W. Williams. Genetic regulation of the expression of the major GABA-A receptor subunits in mouse brain. The 23rd international mammalian genome conference (IMGC), La Jolla, California, November, 2009.

 

8.      Megan K. Mulligan, Zhengsheng Li, Xusheng Wang, Michael F. Miles, Lu Lu, Robert W. Williams. Functional insertion of a B2 SINE in Comt controls 3´ UTR length and generates widespread expression and behavioral differences among inbred strains of mice. The 12th Annual Genes, Brain and Behavior Meeting of IBANGS. 2010.

 

9.      Xusheng Wang, Richa Agarwala, John A Capra, Zugen Chen, Deanna M Church, Daniel C Ciobanu, Zhengsheng  Li, Lu Lu, Khyobeni  Mozhui, Megan K Mulligan, Stanley F Nelson, Katherine S Pollard, Williams L Taylor, Donald B Thomason, Robert W Williams. High-throughput sequencing of the DBA/2J mouse genome. UT-ORNL-KBRIN Bioinformatics submit. 2010.

 

10.  Xusheng Wang, Richa Agarwala, John A Capra, Zugen Chen, Deanna M Church, Daniel C Ciobanu, Zhengsheng  Li, Lu Lu, Khyobeni  Mozhui, Megan K Mulligan, Stanley F Nelson, Katherine S Pollard, Williams L Taylor, Donald B Thomason, Robert W Williams. A whole genome sequence for DBA/2J and its use in reverse complex trait analysis. The 9th annual meeting of the Complex Trait Community. Chicago, IL, USA. May 2010.

 

11.  Khyobeni Mozhui, Xusheng Wang, Megan K. Mulligan, Lu Lu, Robert W. Williams. Exon-Level Analysis of Synaptic Gene Expression: A Neurexin 1 Network in the Hippocampus. The 9th annual meeting of the Complex Trait Community. Chicago, IL, USA. May 2010.

 

12.  Monica M. Jablonski, Hong Lu, Matthew Pullen, Xusheng Wang, Huaijin Guan, Lu Lu, Robert W. Williams. Genetic dissection of the Gpnmb network in the eye. The ARVO 2010 Annual Meeting, Ft Lauderdale, Florida, USA, May, 2010.

 

13.  Lu Lu, Xusheng Wang, Melloni M Cook. Genetic analysis of anxiety-related behavior and gene expression in BXD strains. The 40th annual Behavior Genetics Association (BGA) meeting, Seoul, South Korea, June, 2010.

 

14.  Daniel C Ciobanu, Stephen D Kachman, Autumn M McKnite, Theresa P Bohnert, Nichelle N Ferdinand, Julie K Tart, Judith A Galeota, Timothy W Moural, Seth P Harris, Roman Moreno, Xusheng Wang, Simon Brewer, Max F. Rothschild, Phillip S. Miller, Rodger K. Johnson. Genome-Wide Association Analyses of Reproduction and Disease Susceptibility in Swine. Plant and Animal Genome XIX Conference. San Diego, California, USA, Jan, 2011.

 

 

 

PATENTS                                                                                                                                 )

1.      Weiren Wu, Yongquan Lu, Xusheng Wang. Development of amplified consensus genetic markers in gramineae. (No. CN1769492)