Project 1: The Mouse Brain Library Project 2: Internet Microscopy (iScope) Project 3: Neurocartographer and Segmentation of the MBL Project 4: The Neurogenetics Tool Box


















Principal Investigator/Program Director Williams,Robert W.

  Research Plan
Problems And Issues Addressed

In this project we request funds to continue to develop resources and techniques for high-magnification quantitative analysis of the Mouse Brain Library collection. All four aims of this project are being actively pursued, and our strong Phase I progress and preliminary results justify long-term support for this Neuroinformatics Phase II project. Accomplishing the aims listed below will put a collection of several thousands sectioned brains from genetically defined mice into the hands of the entire biomedical research community for collaborative and independent research.
While our own emphasis is on probing the complex genetic and environmental basis of variation in CNS architecture (QTL mapping), the microscope systems that we are developing will have widespread applicability in other research and teaching programs. The bioinformatics challenges of designing and assembling this complex system are substantial, but the team of investigators (Williams, Park, and Nissanov) have the right combination of expertise in video microscopy, database design, stereology, and image analysis to make this a practical five year objective.

Next Topic

  Aim 1. IScope Microscope Design and Construction.