Project 1: The Mouse Brain Library Project 2: Internet Microscopy (iScope) Project 3: Neurocartographer and Segmentation of the MBL Project 4: The Neurogenetics Tool Box


















Principal Investigator/Program Director Williams,Robert W.


Relationship of project to objectives of the Human Brain Project

Substantial effort toward development of neuroinformatics tools has been expended since the Committee on a National Neural Circuitry Database was convened in October 1989. After the committee published its recommendation (Pechura and Martin 1991), the Human Brain Project was launched, and the new discipline of neuroinformatics blossomed (Koslow and Huerta 1997). The work described in this proposal will link neuronal phenotypes with corresponding genotypes. The influence of the MBL and the NeuroCartographer projects will extend far beyond the field of mouse neurogenetics. The MBL will become a well-traveled bridge connecting neuroanatomical and genome databases in other species. For example, if a QTL is identified on proximal mouse chromosome 7 that controls the volume of the caudate nucleus, then we can look for the homolog of this gene on human chromosome 19 or 11. Data sets generated by the NeuroCartographer project will make it feasible to traverse from mice to humans (and other species) by virtue of structural and genetic homologies. As a result, we will be in a far better position to explore the genetic basis of variation in human CNS structure.



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